Our study aims to understand cellular functions using a bottom-up approach from the single molecule level. To achieve this, we are attempting to elucidate the mechanism by which individual biomolecules or their networks function in a precise manner, by developing novel single-molecule techniques using multidisciplinary approaches, including biophysics, bioMEMS, and chemical biology. In addition, we are developing a methodology to investigate correlations between genetic mutations, dysfunctions, and diseases with single molecule sensitivity, which would provide new insights for biological as well as pharmaceutical studies.

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  Single molecule biophysics of membrane proteins

  We are attempting to elucidate the working mechanism of membrane proteins by developing novel single-molecule techniques.

  References
  PNAS(2018b), Nat Commun(2014)
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  Understand cell functions by bottom-up approach

  We are developing a methodology to investigate correlations between genetic mutations, dysfunctions, and diseases.

  References
  PNAS(2018a), eLife(2018)


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  Social implementation of single molecule technology

  We are attempting to conduct social implimentation of our single molecule technology as drug screening or diagnosis tool.

  References
  Commun Biol(2022), Commun Biol(2021), Lab Chip(2022)